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Invitrogen™ GADD45B Polyclonal Antibody
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Catalog No. PIPA5100741
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100 μL
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PIPA5100741 100 μL
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Catalog No. PIPA5100741 Supplier Invitrogen™ Supplier No. PA5100741
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GADD45B.

Cellcycle progression issubject to arrest at G1 and G2 checkpointsin response to DNA damage, presumablyto allow time for DNA repair prior to entryinto S andMphase, respectively. The p53 tumorsuppressor isrequired for one such G1 checkpoint and functionsto upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry ofcellsinto S phase. Thus, it has been suggested that GADD 45 mayserve as a link between the p53-dependentcellcycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45 beta and GADD 45 gamma, have been shown to be induced by environmentalstresses. GADD 45 beta and GADD 45 gamma are thought to induce p38/JNK activation via MEKK4 activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GADD45B
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GADD45B
Gene Accession No. O75293, P22339
Gene Alias AI323528; DKFZP566B133; Gadd45b; GADD45BETA; growth arrest and DNA damage inducible beta; growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible 45 beta; growth arrest and DNA-damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible, beta; MYD118; myeloid differentiation primary response; myeloid differentiation primary response gene 118; myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118; Unknown (protein for MGC:138134)
Gene Symbols GADD45B
Host Species Rabbit
Immunogen A synthesized peptide derived from human GADD45B(Accession O75293), corresponding to amino acid residues L117-R160.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17873, 299626, 4616
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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