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GADD45B Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986896
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50-198-6896 100 μL
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Catalog No. 50-198-6896 Supplier Bioss Supplier No. BS5904R
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Description

Rabbit Polyclonal Antibody

Cellcycle progression issubject to arrest at G1 and G2 checkpointsin response to DNA damage, presumablyto allow time for DNA repair prior to entryinto S andMphase, respectively. The p53 tumorsuppressor isrequired for one such G1 checkpoint and functionsto upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry ofcellsinto S phase. Thus, it has been suggested that GADD 45 mayserve as a link between the p53-dependentcellcycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45 beta and GADD 45 gamma, have been shown to be induced by environmentalstresses. GADD 45 beta and GADD 45 gamma are thought to induce p38/JNK activation via MEKK4 activation.

Specifications

Antigen GADD45B
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene GADD45B
Gene Accession No. O75293
Gene Alias AI323528; BOS_7788; DKFZP566B133; Gadd45b; GADD45BETA; growth arrest and DNA damage inducible beta; Growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible 45 beta; growth arrest and DNA-damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible, beta; Myd118; myeloid differentiation primary response; myeloid differentiation primary response gene 118; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
Gene Symbols GADD45B
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human GADD45B.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4616
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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