Invitrogen™ GADD45GIP1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5111409	100 μL

Catalog No. PIPA5111409 Supplier Invitrogen™ Supplier No. PA5111409

Description

Rabbit Polyclonal Antibody

Immunogen sequence: ELEAEEREWY PSLATMQESL RVKQLAEEQK RRER Highest antigen sequence indentity to the following orthologs: Rat - 79%, Mouse - 74%.

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).

Specifications

• Antigen: GADD45GIP1
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Gadd45gip1
• Gene Accession No.: Q8TAE8
• Gene Alias: 2310040G17Rik; 39S ribosomal protein L59, mitochondrial; AI425883; CKBBP2; CKbetaBP2; CKII beta binding protein 2; CKII beta-associating protein; CR6 interacting factor 1; CR6-interacting factor 1; CRIF1; GADD45G interacting protein 1; GADD45GIP1; growth arrest- and DNA damage-inducible GADD45G-interacting protein; Growth arrest and DNA damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible, gamma interacting protein 1; Mitochondrial large ribosomal subunit protein mL64; Mrpl59; MRP-L59; p53-responsive gene 6 protein; papillomavirus L2 interacting nuclear protein 1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP1; PLINP-1; PRG6
• Gene Symbols: Gadd45gip1
• Host Species: Rabbit
• Immunogen: Recombinant Protein corresonding to Human GADD45GIP1. Recombinant protein control fragment (Product #RP-103584).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 90480
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG