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GADD45GIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 162601AP150UL

Encompass_Preferred

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Catalog No. 50-173-0835


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Description

Description

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).
Specifications

Specifications

GADD45GIP1
Polyclonal
Unconjugated
GADD45GIP1
CKBBP2, CKII beta associating protein, CR6 interacting factor 1, CRIF1, GADD45GIP1, p53 responsive gene 6 protein, PLINP 1, Plinp1, PRG6
Rabbit
Antigen Affinity Chromatography
RUO
102060, 288916, 90480
-20°C
Liquid
Immunoprecipitation, Western Blot
0.35 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8TAE8, Q9CR59
Gadd45gip1
GADD45GIP1 Fusion Protein Ag9299
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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