MilliporeSigma™ Galactocerebroside, Mouse, Alexa Fluor 647, Clone: mGalC,

Catalog No.	Quantity	Conjugate
MAB342AF647	100 μL	Alexa Fluor 647

Catalog No. MAB342AF647 Supplier MilliporeSigma™ Supplier No. MAB342AF647

Description

Mouse Monoclonal Antibody

Galactocerebroside (GalCer or GalC) is the most frequently found glycosphingolipid in animals. GalCer consist of a ceramide linked to a single galactose residue at the 1-hydroxyl moiety. Cerebrosides are concentrated in nervous tissues where they increase from about 0.02% of the dry weight in human fetal brain to 2% in gray matter and 12% in white matter of adult brain. GalCer is a specific cell-surface antigenic marker for oligodendrocytes and schwann cells. GalCer is the largest single component of the myelin sheath of nerves. GalCer synthesis therefore serves as a measurement of myelin formation or remyelination. Krabbe disease is an autosomal recessive sphingolipidosis caused by deficient activity of the lysosomal hydrolase galactosylceramide beta-galactosidase (GALC). GALC mediates the degradation of GalCer and other terminal beta-Gal-containing sphingolipids, including psychosine (galactosylsphingosine). Increased psychosine levels are believed to lead to widespread destruction of oligodendroglia in the CNS and to subsequent demyelination.

Specifications

• Antigen: Galactocerebroside
• Applications: Immunocytochemistry
• Classification: Monoclonal
• Clone: mGalC
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Alexa Fluor 647
• Formulation: Purified mouse IgG3 Alexa Fluor™ 647 conjugate in PBS with 1.5% BSA and 0.09% Sodium Azide.
• Host Species: Mouse
• Immunogen: Synaptic plasma membranes from bovine hippocampus (Ranscht, B. et al. (1982) Proc. Natl. Acad. Sci. U. S. A. 79(8):2709-2713).
• Purification Method: Protein A Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Neuroscience
• Primary or Secondary: Primary
• Test Specificity: Galactocerebroside (GalC), sulfatide, psychosine and other galactolipids. Cross-reacts with the sulfatide ester of GalC, but to a 16-fold lesser extent. No cross-reactivity with sphingosine, ceramide, mixed ganglioside or glucocerebroside. Binds specifically to the surface of oligodendrocytes and Schwann cells (Ranscht, B. et al. (1982) Proc. Natl. Acad. Sci. U. S. A. 79(8):2709-2713).
• Target Species: Bovine
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Isotype: IgG3

For Research Use Only. Not for use in diagnostic procedures.