GALE Mouse anti-Canine, Human, Rat, Clone: OTI1C4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF502146

Catalog No. 50-166-1078

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (′peripheral′ form) to severe (′generalized′ form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Specifications

• Antigen: GALE
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GALE
• Gene Alias: SDR1E1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100855555, 114860, 2582
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1C4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P18645, Q14376
• Gene Symbols: GALE
• Immunogen: Full length human recombit protein of human GALE produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Human, Rat
• Product Type: Antibody
• Isotype: IgG1