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GALE Mouse anti-Canine, Human, Rat, Clone: OTI1C4, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA502146

Catalog No. 50-167-3226


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Description

Description

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ( ft.peripheral ft. form) to severe ( ft.generalized ft. form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
Specifications

Specifications

GALE
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P18645, Q14376
SDR1E1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
100855555, 114860, 2582
Immunohistochemistry (Paraffin), Western Blot
OTI1C4
Unconjugated
GALE
Liquid
GALE
Full length human recombit protein of human GALE produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Rat
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