GALE Mouse anti-Canine, Human, Rat, Clone: OTI1C4, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA502146
DescriptionThis gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ( ft.peripheral ft. form) to severe ( ft.generalized ft. form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
|100855555, 114860, 2582|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of human GALE produced in HEK293T cell.|
|Canine, Human, Rat|
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