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Invitrogen™ GALE Polyclonal Antibody
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Catalog No. FEPA5144982
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100 μL
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FEPA5144982 100 μL
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Catalog No. FEPA5144982 Supplier Invitrogen™ Supplier No. PA5144982
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RSVEFEEMDI LDQGALQRLF KKYSFMAVIH FAGLKAVGES VQKPLDYYRV NLTGTIQLLE IMKAHGVKNL VFSSSATVYG NPQYLPLDEA HPTGGCTNPY GKSKFFIEEM IRDLCQADKT WNAVL Antigen sequence identity: Mouse 94%; Rat 91%.

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GALE
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GALE
Gene Accession No. Q14376
Gene Alias 2310002A12Rik; AI323962; EGK_00373; galactose-4-epimerase, UDP; galactose-4-epimerase, UDP-; galactowaldenase; Gale; SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP galactose-4'-epimerase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase; UDP-galactose-4-epimerase; UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-glucose 4-epimerase; UDP-N-acetylgalactosamine 4-epimerase; UDP-N-acetylglucosamine 4-epimerase
Gene Symbols GALE
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 58-182. Recombinant protein control fragment (Product #RP-109862).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2582
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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