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Invitrogen™ GALE Polyclonal Antibody
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Catalog No. PIPA544158
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100 μL
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PIPA544158 100 μL
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Catalog No. PIPA544158 Supplier Invitrogen™ Supplier No. PA544158
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Description

Rabbit Polyclonal Antibody

Peptide sequence: AEKVLVTGGA GYIGSHTVLE LLEAGYLPVV IDNFHNAFRG GGSLPESLRR Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 86%; Human: 100%; Mouse: 91%; Pig: 91%; Rabbit: 92%; Rat: 91%.

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GALE
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene GALE
Gene Accession No. Q14376
Gene Alias 2310002A12Rik; AI323962; EGK_00373; galactose-4-epimerase, UDP; galactose-4-epimerase, UDP-; galactowaldenase; Gale; SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP galactose-4'-epimerase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase; UDP-galactose-4-epimerase; UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-glucose 4-epimerase; UDP-N-acetylgalactosamine 4-epimerase; UDP-N-acetylglucosamine 4-epimerase
Gene Symbols GALE
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human GALE (aa 2-51).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2582
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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