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Invitrogen™ GALE Polyclonal Antibody
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Catalog No. PIPA552423
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100 μL
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PIPA552423 100 μL
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Catalog No. PIPA552423 Supplier Invitrogen™ Supplier No. PA552423
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QGIPNNLMPY VSQVAIGRRE ALNVFGNDYD TEDGTGVRDY IHVVDLAKGH IAALRKLKEQ CGCRIYNLGT GTGYSVLQMV QAMEKASGKK IPYKVVARRE GDVAA Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GALE
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GALE
Gene Accession No. P18645, Q14376, Q8R059
Gene Alias 2310002A12Rik; AI323962; EGK_00373; galactose-4-epimerase, UDP; galactose-4-epimerase, UDP-; galactowaldenase; Gale; SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP galactose-4'-epimerase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase; UDP-galactose-4-epimerase; UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-glucose 4-epimerase; UDP-N-acetylgalactosamine 4-epimerase; UDP-N-acetylglucosamine 4-epimerase
Gene Symbols GALE
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GALE. Recombinant protein control fragment (Product #RP-88675).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114860, 2582, 74246
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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