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Invitrogen™ GALE Polyclonal Antibody
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Catalog No. PIPA579296
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100 μg
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PIPA579296 100 μg
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Catalog No. PIPA579296 Supplier Invitrogen™ Supplier No. PA579296
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human SiHa whole cell, human HepG2 whole cell, human HEL whole cell, human Caco-2 whole cell, human A549 whole cell, rat liver tissue, rat PC-12 whole cell, mouse stomach tissue, mouse liver tissue . IHC: human mammary cancer tissue, human colon cancer tissue, human lung cancer tissue, mouse intestine tissue, rat kidney tissue.

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GALE
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene GALE
Gene Accession No. P18645, Q14376, Q8R059
Gene Alias 2310002A12Rik; AI323962; EGK_00373; galactose-4-epimerase, UDP; galactose-4-epimerase, UDP-; galactowaldenase; Gale; SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP galactose-4'-epimerase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase; UDP-galactose-4-epimerase; UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-glucose 4-epimerase; UDP-N-acetylgalactosamine 4-epimerase; UDP-N-acetylglucosamine 4-epimerase
Gene Symbols GALE
Host Species Rabbit
Immunogen E. coli-derived human GALE recombinant protein (Position: M1-N340).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114860, 2582, 74246
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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