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  5. Tocris Bioscience™ Galunisertib

Tocris Bioscience™ Galunisertib
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Catalog No. 69565
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Quantity:
5 mg
25 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

ALK4 and ALK5 (TGFβRI) inhibitor

Galunisertib is an ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B. Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo. Also reverses TGFβ-mediated suppression of T cell proliferation. Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo. Used as component of growth media for urothelial organoids. Orally bioavailable.

Specifications

Chemical Name or Material 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
CAS 700874-72-2
Quantity 5 mg
Target TGF-beta Receptor Inhibitors
Molecular Formula C22H19N5O
Formula Weight 369.43
Product Type Inhibitor
Purity 98%
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