ALK4 and ALK5 (TGFβRI) inhibitor
Manufacturer: Tocris™ 6956/5
DescriptionGalunisertib is an ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B. Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo. Also reverses TGFβ-mediated suppression of T cell proliferation. Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo. Used as component of growth media for urothelial organoids. Orally bioavailable.
|ALK4 and ALK5 (TGFβRI) inhibitor|
|TGF-beta Receptor Inhibitors|
Safety and Handling
Recommended Storage : Store at -20°C