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Tocris™ Galunisertib

ALK4 and ALK5 (TGFβRI) inhibitor

Manufacturer:  Tocris™ 6956/5

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Catalog No. 69-565

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Galunisertib is an ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B. Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo. Also reverses TGFβ-mediated suppression of T cell proliferation. Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo. Used as component of growth media for urothelial organoids. Orally bioavailable.


ALK4 and ALK5 (TGFβRI) inhibitor
TGF-beta Receptor Inhibitors
4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
5 mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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