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Tocris™ Galunisertib

ALK4 and ALK5 (TGFβRI) inhibitor

Manufacturer:  Tocris™ 6956/5

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Catalog No. 69-565


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Description

Description

Galunisertib is an ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B. Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo. Also reverses TGFβ-mediated suppression of T cell proliferation. Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo. Used as component of growth media for urothelial organoids. Orally bioavailable.
Specifications

Specifications

369.43
ALK4 and ALK5 (TGFβRI) inhibitor
TGF-beta Receptor Inhibitors
700874-72-2
C22H19N5O
98%
4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
5 mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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