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  5. R&D Systems™ Galunisertib

R&D Systems™ Galunisertib
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Catalog No. 69565 Shop All Novus Products
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Catalog No. Quantity
69-565 5 mg
69-562-5 25 mg
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Catalog No. 69-565 Supplier R&D Systems™ Supplier No. 6956/5

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Description

A Tocris product, part of R&D Systems. ALK4 and ALK5 (TGFβRI) inhibitor

Galunisertib is an ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively). Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B. Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo. Also reverses TGFβ-mediated suppression of T cell proliferation. Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo. Used as component of growth media for urothelial organoids. Orally bioavailable.

Specifications

Chemical Name or Material 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
CAS 700874-72-2
Quantity 5 mg
Product Line Tocris
Target TGF-beta Receptor Inhibitors
Molecular Formula C22H19N5O
Formula Weight 369.43
Product Type Inhibitor
Purity 98%
Product Title
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