Invitrogen™ gamma Actin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527526

Catalog No. PIPA527526

Description

Recommended positive controls: NIH-3T3. Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%), Dog (100%), Chicken (99%), Chimpanzee (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: gamma Actin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACTG1
• Gene Alias: ACT; ACTG; Actg1; actin; actin gamma; actin gamma 1; actin, cytoplasmic 2; Actin, cytoplasmic 2, N-terminally processed; Actin, cytoplasmic type 5; actin, cytoplasmic, type 5; actin, gamma 1; actin, gamma 1 propeptide; actin, gamma, cytoplasmic 1; Actl; AL023024; beta actin; beta-actin FE-3; BRWS2; cytoplasmic 2; cytoplasmic ACTG1; cytoplasmic type 5; cytoskeletal gamma-actin; cytoskeleton actin; deafness, autosomal dominant 20; deafness, autosomal dominant 26; DFNA20; DFNA26; E51; epididymis luminal protein 176; gamma 1 propeptide; gamma actin; gamma-actin; HEL-176; type 5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11465, 71
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.26 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P63260, P63261
• Gene Symbols: ACTG1
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 144 and 351 of Human gamma Actin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov