Invitrogen™ gamma Adducin Polyclonal Antibody

Catalog No.	Quantity
PIPA5106543	100 μL

Catalog No. PIPA5106543 Supplier Invitrogen™ Supplier No. PA5106543

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ADD3.

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.

Specifications

• Antigen: gamma Adducin
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: ADD3
• Gene Accession No.: Q62847, Q9QYB5, Q9UEY8
• Gene Alias: ADD3; ADDG; Addl; adducin 3; adducin 3 (gamma); Adducin gamma; adducin-like protein 70; AI463285; CPSQ3; cytoskeletal protein; gamma-adducin; potein kinase C binding protein 35H; protein kinase C-binding protein 35H; R75380
• Gene Symbols: ADD3
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human ADD3(Accession Q9UEY8), corresponding to amino acid residues Q432-P482.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 120, 25230, 27360
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG