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Invitrogen™ Ganglioside GM2 Chimeric Recombinant Rabbit Monoclonal Antibody (L55-81)
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Catalog No. PIMA548069
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Quantity:
200 μg
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Catalog No. Quantity
PIMA548069 200 μg
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Catalog No. PIMA548069 Supplier Invitrogen™ Supplier No. MA548069
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: L55-81 binds specifically to GM2 ganglioside; this antibody shows no reactivity towards GM1, GM3, GD2 or normal tissues- the L55-81 epitope contains both a GalNAc and sialic acid bound to lactose. Ganglioside GM2 (GalNAcBeta1-4(NeuNAcalpha2-3)GalBeta1-4GlcBeta-1ceramide) is a glycosphingolipid present on the cell surface and a major tumor-differentiation antigen in human melanoma and hepatoma.

Ganglioside GM2 is a glycosphingolipid found in the plasma membrane of cells, particularly in the nervous system. It is composed of a ceramide lipid tail and a complex carbohydrate head group that contains sialic acid residues. The function of Ganglioside GM2 is not fully understood, but it is believed to play a role in cell signaling and communication, as well as in the formation and maintenance of the myelin sheath that surrounds nerve cells. Mutations in the genes responsible for the synthesis or degradation of Ganglioside GM2 can result in various neurological disorders, including Tay-Sachs disease and Sandhoff disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ganglioside GM2 Chimeric
Applications ELISA, Functional Assay, Immunohistochemistry, Immunocytochemistry
Classification Recombinant Monoclonal
Clone L55-81
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene ALB
Gene Accession No. P02769
Host Species Rabbit
Immunogen L55-81 was prepared by isolating EBV-immortalized peripheral blood B lymphocytes from a human donor with melanoma.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 280717
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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