GANP Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A303127AT

Catalog No. 50-156-4331

Description

The recommended shelf life for this product is 1 year from date of receipt.

GANP (germinal center-associated nuclear protein) is up-regulated selectively in germinal centers and carries an MCM-binding domain in the carboxyl-terminal side. It was found that a region (from 414 to 550 aa) in GANP molecule that is slightly similar to the known DNA-primase component p49. The recombit GANP fragment covering this region synthesizes RNA primers for extension by DNA polymerase I with single-stranded DNA templates in vitro. GANP DNA-primase activity is controlled by phosphorylation at Ser(502) that is induced by CD40-mediated signaling in vitro and in the germinal center B cells stimulated with antigen in vivo. Overexpression of ganp cDNA in Daudi B cells caused the increased DNA synthesis more than the levels of the mock-transfectants. These evidences suggested that the novel DNA-primase GANP is involved in regulation of cell proliferation of antigen-driven B cells in germinal centers.

Specifications

• Antigen: GANP
• Classification: Polyclonal
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: O60318
• Gene Symbols: MCM3AP
• Immunogen: Between 1 and 50
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: MCM3AP
• Gene Alias: GANP, MAP80, 80 kDa MCM3-associated protein, MCM3 import protein, MCM3 minichromosome maintece deficient 3 associated protein, germinal center-associated nuclear protein, minichromosome maintece deficient 3-associated protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8888
• Content And Storage: 4° C
• Form: Liquid