GAPDHS Mouse anti-Human, Clone: OTI1F6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF505454

Catalog No. 50-166-3653

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. Because GAPDH is a protein expressed in large amounts and which is required at all times for important "house keeping" functions, levels of GAPDH mRNA are often measured and used as standards in studies of mRNA expression. Increasingly, scientists are making use of specific antibodies to GAPDH in comparable studies of levels of protein expression. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer′s disease, and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington′s disease. Associations with actin and tubulin have also been reported. The protein may also have a role in the regulation of apoptosis, and interestingly migrates from the cytoplasm into the nucleus when cells become apoptotic.

Specifications

• Antigen: GAPDHS
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GAPDHS
• Gene Alias: GAPD2, GAPDH-2, GAPDS, HEL-S-278, HSD-35
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26330
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1F6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O14556
• Gene Symbols: GAPDHS
• Immunogen: Full length human recombit protein of human GAPDHS produced in HEK293T
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a