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Invitrogen™ GAPVD1 Polyclonal Antibody
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Catalog No. PIPA556124
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PIPA556124 100 μL
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Catalog No. PIPA556124 Supplier Invitrogen™ Supplier No. PA556124
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AMTGSEEGDP RTKSSLGKFD KSCVAAFLDV VIGGRAVETP PLSSVNLLEG LSRTVVYITY SQLITLVNFM KSVMSGDQLR EDRMALDNLL ANLP Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GAPVD1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Gapvd1
Gene Accession No. Q14C86
Gene Alias 2010005B09Rik; 4432404J10Rik; AW108497; DKFZP434C212; GAPEX5; GAPex-5; GAPVD1; GTPase activating protein and VPS9 domains 1; GTPase-activating protein and VPS9 domain-containing protein 1; hypothetical protein LOC436693; Kiaa1521; MGC138847; MGC138848; mKIAA1521; rab5-activating protein 6; RAP6; RGD1307479; RME-6; zgc:92666
Gene Symbols Gapvd1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GAPVD1. Recombinant protein control fragment (Product #RP-93044).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26130
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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