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Invitrogen™ GAS2L1 Polyclonal Antibody
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Catalog No. PIPA582704
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100 μL
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PIPA582704 100 μL
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Catalog No. PIPA582704 Supplier Invitrogen™ Supplier No. PA582704
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RLSRVSSPSP ELGTTPASIF RTPLQLDPQQ EQQLFRRLEE EFLANARALE AVASVTPTGP APDPARAPDP PAPDSAYCSS SSSSSSLSVL GGKCG Highest antigen sequence indentity to the following orthologs: Mouse - 83%, Rat - 32%.

The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 or caspase-7) at Asparagine 278 during apoptosis. The cleaved form of Gas2 dramatically induces the re-arrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated, but when hyperphosphorylated it will accumulate at membrane ruffles, indicating Gas2 involvement in that process. Gar22 (Gas2-related protein on chromosome 22), also designated growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one CH (calponinhomo-logy) domain. It is thought to be involved in the cross-linking of microtubules and microfilaments.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GAS2L1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GAS2L1
Gene Accession No. Q99501
Gene Alias 4930500E24Rik; D0Jmb1; Gar22; GAS2L1; GAS2-like protein 1; GAS2-related protein; GAS2-related protein on chromosome 22; growth arrest specific 2 like 1; growth arrest-specific 2 like 1; growth arrest-specific protein 2-like 1; TU-71.1
Gene Symbols GAS2L1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GAS2L1. Recombinant protein control fragment (Product #RP-108158).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10634
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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