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Invitrogen™ GAS2L1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA582704

Catalog No. PIPA582704


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Description

Description

Immunogen sequence: RLSRVSSPSP ELGTTPASIF RTPLQLDPQQ EQQLFRRLEE EFLANARALE AVASVTPTGP APDPARAPDP PAPDSAYCSS SSSSSSLSVL GGKCG.

The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 or caspase-7) at Asparagine 278 during apoptosis. The cleaved form of Gas2 dramatically induces the re-arrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated, but when hyperphosphorylated it will accumulate at membrane ruffles, indicating Gas2 involvement in that process. Gar22 (Gas2-related protein on chromosome 22), also designated growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one CH (calponinhomo-logy) domain. It is thought to be involved in the cross-linking of microtubules and microfilaments.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GAS2L1
Polyclonal
Unconjugated
GAS2L1
4930500E24Rik; D0Jmb1; Gar22; GAS2L1; GAS2-like protein 1; GAS2-related protein; GAS2-related protein on chromosome 22; growth arrest specific 2 like 1; growth arrest-specific 2 like 1; growth arrest-specific protein 2-like 1; TU-71.1
Rabbit
Antigen affinity chromatography
RUO
10634, 360973, 78926
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.6 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q8JZP9, Q99501
GAS2L1
Recombinant protein corresponding to Human GAS2L1. Recombinant protein control fragment (Product #RP-108158).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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