Invitrogen™ GASP2 Polyclonal Antibody

Catalog No.	Quantity
PIPA560654	100 μL

Catalog No. PIPA560654 Supplier Invitrogen™ Supplier No. PA560654

Description

Rabbit Polyclonal Antibody

Immunogen sequence: STCERECSRD QDCAAAEKCC INVCGLHSCV AARFPGSPAA PTTAASCEGF VCPQQGSDCD I Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 82%.

The GASP2 gene encodes for a protein known as G protein-coupled receptor-associated sorting protein 2. GASP2 is involved in the regulation of G protein-coupled receptors (GPCRs), which are crucial for transmitting signals from the external environment to the inside of a cell. This protein plays a key role in the intracellular trafficking and sorting of GPCRs, affecting their recycling and degradation pathways, which are critical for receptor resensitization and downregulation. GASP2 assists in marking GPCRs for degradation post endocytosis, thereby influencing receptor availability on the cell surface and modulating cellular responsiveness to ligands. Dysregulation of GASP2 expression or function can impact GPCR signaling pathways, potentially affecting various physiological processes and contributing to disease states where GPCR signaling is altered, such as in certain neurological disorders and cancers. The role of GASP2 in GPCR regulation makes it a point of interest for therapeutic targeting to modulate GPCR-related signaling pathways for clinical benefits in diverse diseases.

Specifications

• Antigen: GASP2
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: WFIKKN1
• Gene Accession No.: Q96NZ8
• Gene Alias: C16orf12; GASP2; GASP-2; Growth and differentiation factor-associated serum protein 2; hGASP-2; PSEC0040; RJD2; WAP four-disulfide core domain 20A; WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing protein; WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; WAP, FS, Ig, KU, and NTR-containing protein; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; WFDC20A; WFIKKN; WFIKKN1
• Gene Symbols: WFIKKN1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human GASP2. Recombinant protein control fragment (Product #RP-102961).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 117166
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG