Invitrogen™ GATA2/GATA3 Recombinant Rabbit Monoclonal Antibody (1K8H6)

Catalog No.	Quantity
PIMA535637	100 μL

Catalog No. PIMA535637

Supplier: Invitrogen™ MA535637

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SAARGEDKDG.

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.

Specifications

• Antigen: GATA2/GATA3
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 1K8H6
• Concentration: 1.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: GATA2
• Gene Accession No.: O09100, P23769, P23771, P23772, Q924Y4
• Gene Alias: DCML; EMBL:AAK51128.1}; endothelial transcription factor GATA-2; GATA binding protein 2; GATA binding protein 3; Gata2; Gata-2; gata2 {ECO:0000312; Gata3; Gata-3; GATA-binding factor 3; GATA-binding protein 2; GATA-binding protein 3; GATA-bindning protein 2; HDR; HDRS; IMD21; jal; MGC2346; MGC5199; MGC5445; MONOMAC; NFE1B; trans-acting T-cell-specific transcription factor GATA-3
• Gene Symbols: GATA2, GATA3
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human GATA2/3 (NP_1160272).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14461, 14462, 25159, 2624, 2625, 85471
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG