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Invitrogen™ GATA2/GATA3 Polyclonal Antibody
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Catalog No. PIPA536109
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100 μL
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PIPA536109 100 μL
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Catalog No. PIPA536109 Supplier Invitrogen™ Supplier No. PA536109
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Description

Rabbit Polyclonal Antibody

Purity is >95% by SDS-PAGE.

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GATA2/GATA3
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene GATA2
Gene Accession No. O09100, P23769, P23771, P23772
Gene Alias DCML; EMBL:AAK51128.1}; endothelial transcription factor GATA-2; GATA binding protein 2; GATA binding protein 3; Gata2; Gata-2; gata2 {ECO:0000312; Gata3; Gata-3; GATA-binding factor 3; GATA-binding protein 2; GATA-binding protein 3; GATA-bindning protein 2; HDR; HDRS; IMD21; jal; MGC2346; MGC5199; MGC5445; MONOMAC; NFE1B; trans-acting T-cell-specific transcription factor GATA-3
Gene Symbols GATA2, GATA3
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 270-318 of human GATA2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14461, 14462, 2624, 2625
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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