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Invitrogen™ GATA3 Monoclonal Antibody (1A10D1)
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Catalog No. PIMA515387
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100 μL
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PIMA515387 100 μL
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Catalog No. PIMA515387 Supplier Invitrogen™ Supplier No. MA515387
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Description

Mouse Monoclonal Antibody

MA5-15387 targets GATA3 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15387 immunogen is purified recombinant fragment of GATA3 (aa175-388) expressed in E. Coli.

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GATA3
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1A10D1
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene GATA3
Gene Accession No. P23771
Gene Alias EGK_19445; GATA binding factor-3; GATA binding protein 3; GATA binding protein-3; GATA3; Gata-3; GATA-binding factor 3; GATA-binding protein 3; HDR; HDRS; jal; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3; Transacting T-cell-specific transcription factor GATA-3
Gene Symbols GATA3
Host Species Mouse
Immunogen Purified recombinant fragment of GATA3 (aa175-388) expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2625
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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