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GATA3 Mouse anti-Human, Clone: OTI10G7, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF809219

Encompass_Preferred

Catalog No. 50-166-9350


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages.
Specifications

Specifications

GATA3
Monoclonal
Unconjugated
GATA3
HDR, HDRS
Mouse
Affinity Chromatography
RUO
2625
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Immunohistochemistry (Paraffin), Western Blot
OTI10G7
PBS with 8% trehalose and no preservative; pH 7.3
P23771
GATA3
Human recombit protein fragment corresponding to amino acids 155-443 of human GATA3 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG2b
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