Invitrogen™ GATM Polyclonal Antibody

Catalog No.	Quantity
PIPA5109756	100 μL

Catalog No. PIPA5109756 Supplier Invitrogen™ Supplier No. PA5109756

Description

Rabbit Polyclonal Antibody

Immunogen sequence: STQAATASSR NSCAADDKAT EPLPKDCPVS SYNEWDPLEE VIVGRAENAC VPPFTIEVKA NTYEKYWPFY QKQGGHYFPK DHLKKAVAEI EEMCNILKTE GVTVRRPDPI DWSLKYKTPD FESTGLYSAM PRDILIVVGN EIIEAPMAWR SRFFEYRAYR SIIKDYFHRG AKWTTAPKPT MADELYNQDY PIHSVEDRHK LAAQGKFVTT EFEPCFDAAD FIRAGRDIFA QRSQVTNYLG IEWMRRHLAP DYRVHIISFK DPNPMHIDAT FNIIGPGIVL SNPDRPCHQI DLFKKAGWTI ITPPTPIIPD DHPLWMSSKW LSMNVLMLDE KRVMVDANEV PIQKMFEKLG ITTIKVNIRN ANSLGGGFHC WTCDVRRRGT LQSYLD.

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family. Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and consists of a homodimer, with equilibrium between monomeric and dimeric forms favoring a monomer subunit structure. AGAT localizes to mitochondrial inner membranes, peripheral membranes and cytoplasm. Biallelically expressed in placenta and fetal tissues, AGAT is also expressed in brain, heart, liver, lung, salivary gland and skeletal muscle tissue, with high expression in kidney. AGAT is elevated in the myocardium during heart failure and is decreased in inter-uterine growth restriction (IUGR)-associated placenta. AGAT catalyzes biosynthesis of guanidinoacetate, the immediate precursor of creatine, which plays a vital role in energy metabolism in muscle tissues. AGAT defects are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay or regression, mental retardation, severe disturbance of expressive and cognitive speech and severe depletion of creatine/phosphocreatine in brain. AGAT may be linked to embryonic and central nervous system development and may function in heart failure response by elevating local creatine synthesis.

Specifications

• Antigen: GATM
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 2.6 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene: GATM
• Gene Accession No.: P50440, P50442, Q9D964
• Gene Alias: 1810003P21Rik; Agat; AI314789; AT; CCDS3; GATM; glycine amidinotransferase; glycine amidinotransferase (L-arginine:glycine amidinotransferase); glycine amidinotransferase, mitochondrial; L-arginine: glycine amidinotransferase; l-arginine:glycine amidinotransferase; testicular secretory protein Li 19; transamidinase
• Gene Symbols: GATM
• Host Species: Rabbit
• Immunogen: Recombinant protein (or fragment)
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2628, 67092, 81660
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov