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Invitrogen™ GATSL3 Polyclonal Antibody
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Catalog No. PIPA5139983
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100 μL
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PIPA5139983 100 μL
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Catalog No. PIPA5139983 Supplier Invitrogen™ Supplier No. PA5139983
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: EQDLSVVIHT LAQEFDIYRE VGGEPVPVTR DDSSNGFPRT QHGPSPTVHP IQSPQNRFCV LTLDPET Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 94%.

GATSL3 functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GATSL3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Castor1
Gene Accession No. Q8WTX7
Gene Alias 2410008K03Rik; CASTOR1; cellular arginine sensor for mTORC1 protein 1; Cytosolic arginine sensor for mTORC1 subunit 1; Gats protein; GATS protein like 3; GATS protein-like 3; GATSL3; GATS-like protein 3; GATS-like protein 3; cytosolic arginine sensor for mTORC1 subunit 1; RGD1304774
Gene Symbols Castor1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CASTOR1. Recombinant protein control fragment (Product #RP-109325).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 652968
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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