Invitrogen™ GATSL3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5139983

Catalog No. PIPA5139983

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: EQDLSVVIHT LAQEFDIYRE VGGEPVPVTR DDSSNGFPRT QHGPSPTVHP IQSPQNRFCV LTLDPET.

GATSL3 functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

Specifications

• Antigen: GATSL3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Castor1
• Gene Alias: 2410008K03Rik; CASTOR1; cellular arginine sensor for mTORC1 protein 1; Cytosolic arginine sensor for mTORC1 subunit 1; Gats protein; GATS protein like 3; GATS protein-like 3; GATSL3; GATS-like protein 3; GATS-like protein 3; cytosolic arginine sensor for mTORC1 subunit 1; RGD1304774
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 652968
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8WTX7
• Gene Symbols: Castor1
• Immunogen: Recombinant protein corresponding to Human CASTOR1. Recombinant protein control fragment (Product #RP-109325).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG