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Invitrogen™ GBP1 Polyclonal Antibody
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Catalog No. PIPA587281
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100 μL
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Catalog No. Quantity
PIPA587281 100 μL
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Catalog No. PIPA587281 Supplier Invitrogen™ Supplier No. PA587281
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Description

Rabbit Polyclonal Antibody

Purity is > 95% by SDS-PAGE.

GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GBP1
Applications Western Blot, Immunohistochemistry (Paraffin), Western Blot, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene GBP1
Gene Accession No. P32455
Gene Alias GBP1; Gbp-1; Gbp2b; GTP-binding protein 1; guanine nucleotide-binding protein 1; guanylate binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; guanylate binding protein 2b; guanylate nucleotide binding protein 1; guanylate-binding protein 1; huGBP-1; interferon-gamma-inducible protein MAG-1; interferon-induced guanylate-binding protein 1; Mag-1; Mpa1; Mpa-1
Gene Symbols GBP1
Host Species Rabbit
Immunogen Recombinant full length Human GBP1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2633
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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