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Invitrogen™ GBP1 Polyclonal Antibody
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Catalog No. PIPA593280
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100 μL
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PIPA593280 100 μL
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Catalog No. PIPA593280 Supplier Invitrogen™ Supplier No. PA593280
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ELAAQLEKKR DDFCKQNQEA SSDRCSALLQ VIFSPLEEEV KAGIYSKPGG YRLFVQKLQD LKKKYYEEPR KGIQAEEILQ TYLKSKESMT DAILQTDQTL TEKEKEIEVE RVKAESAQAS AKMLQEMQRK NEQMMEQKER SYQEHLKQLT EKMENDRVQL LKEQERTLAL KLQEQEQLLK EGFQKESRIM KNEIQDLQTK MRRRKACTIS; Positive Samples: 5637(HTB-9); Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor.

GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GBP1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.97 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GBP1
Gene Accession No. P32455
Gene Alias GBP1; Gbp-1; Gbp2b; GTP-binding protein 1; guanine nucleotide-binding protein 1; guanylate binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; guanylate binding protein 2b; guanylate nucleotide binding protein 1; guanylate-binding protein 1; huGBP-1; interferon-gamma-inducible protein MAG-1; interferon-induced guanylate-binding protein 1; Mag-1; Mpa1; Mpa-1
Gene Symbols GBP1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 383-592 of human GBP1 (NP_0020442).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2633
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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