Invitrogen™ GCH1 Monoclonal Antibody (OTI1E3)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527277

Catalog No. PIMA527277

Description

GCH1 Monoclonal Antibody for Western Blot, IHC (P)

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Specifications

• Antigen: GCH1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P30793
• Gene Symbols: GCH1
• Immunogen: Full length human recombinant protein of GCH1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E3
• Conjugate: Unconjugated
• Gene: GCH1
• Gene Alias: dystonia 14; DYT14; DYT5; DYT5a; GCH; Gch1; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTPCH; GTP-CH; GTPCH1; GTP-CH-1; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I; HPABH4B
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2643
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid