GCH1 Mouse anti-Human, Clone: OTI2D12, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF810248

Catalog No. 50-166-9969

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with maligt hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Specifications

• Antigen: GCH1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GCH1
• Gene Alias: DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2643
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2D12
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P30793
• Gene Symbols: GCH1
• Immunogen: Full length human recombit protein of human GCH1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a