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Invitrogen™ GCH1 Polyclonal Antibody
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Catalog No. PIPA5120098
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100 μL
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PIPA5120098 100 μL
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Catalog No. PIPA5120098 Supplier Invitrogen™ Supplier No. PA5120098
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Description

Rabbit Polyclonal Antibody

Positive test controls include: THP-1, Mouse liver, Mouse brain, Mouse spleen, Rat lung, Rat liver. The target is usually found in the following locations: Cytoplasm, Nucleus.

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GCH1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.76 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene GCH1
Gene Accession No. P22288, P30793, Q05915
Gene Alias dystonia 14; DYT14; DYT5; DYT5a; GCH; Gch1; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTPCH; GTP-CH; GTPCH1; GTP-CH-1; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I; HPABH4B
Gene Symbols GCH1
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14528, 2643, 29244
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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