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Invitrogen™ GCH1 Polyclonal Antibody
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Catalog No. PIPA5103865
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100 μL
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PIPA5103865 100 μL
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Catalog No. PIPA5103865 Supplier Invitrogen™ Supplier No. PA5103865
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GCH1.

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GCH1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GCH1
Gene Accession No. P22288, P30793, Q05915
Gene Alias dystonia 14; DYT14; DYT5; DYT5a; GCH; Gch1; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTPCH; GTP-CH; GTPCH1; GTP-CH-1; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I; HPABH4B
Gene Symbols GCH1
Host Species Rabbit
Immunogen A synthesized peptide derived from human GCH1(Accession P30793), corresponding to amino acid residues A36-P86.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14528, 2643, 29244
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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