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Invitrogen™ GCK Monoclonal Antibody (4G6)
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Catalog No. PIMA515878
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100 μL
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Catalog No. Quantity
PIMA515878 100 μL
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Catalog No. PIMA515878 Supplier Invitrogen™ Supplier No. MA515878
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Description

Mouse Monoclonal Antibody

MA5-15878 targets GCK in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15878 immunogen is purified recombinant fragment of human GCK expressed in E. Coli. . MA5-15878 detects GCK which has a predicted molecular weight of approximately 52kDa.

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
TRUSTED_SUSTAINABILITY

Specifications

Antigen GCK
Applications ELISA, Western Blot
Classification Monoclonal
Clone 4G6
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene GCK
Gene Accession No. P35557
Gene Alias ATP:D-hexose 6-phosphotransferase; FGQTL3; GC kinase; Gck; Gk; GLK; Gls006; glucokinase; glucokinase (hexokinase 4); glucokinase variant 3; GLUKA; hexokinase 4; hexokinase D, pancreatic isozyme; hexokinase type IV; Hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; Hlb62; HXKP; LGLK; MEKKK 2; MODY2; RNGK2
Gene Symbols GCK
Host Species Mouse
Immunogen Purified recombinant fragment of human GCK expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2645
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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