GCK Mouse anti-Human, Clone: OTI3E3, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500459

Catalog No. 50-165-9531

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Specifications

• Antigen: GCK
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GCK
• Gene Alias: FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2645
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3E3
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P35557
• Gene Symbols: GCK
• Immunogen: Full length human recombit protein of human GCK produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1