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Invitrogen™ GCK Polyclonal Antibody
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Catalog No. PIPA515072
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200 μL
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Catalog No. Quantity
PIPA515072 200 μL
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Catalog No. PIPA515072 Supplier Invitrogen™ Supplier No. PA515072
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Description

Rabbit Polyclonal Antibody

GCK Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
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Specifications

Antigen GCK
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene GCK
Gene Accession No. P17712, P35557, P52792
Gene Alias ATP:D-hexose 6-phosphotransferase; FGQTL3; GC kinase; Gck; Gk; GLK; Gls006; glucokinase; glucokinase (hexokinase 4); glucokinase variant 3; GLUKA; hexokinase 4; hexokinase D, pancreatic isozyme; hexokinase type IV; Hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; Hlb62; HXKP; LGLK; MEKKK 2; MODY2; RNGK2
Gene Symbols GCK
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GCK.
Purification Method Ammonium sulfate precipitation, Size-exclusion - Dialysis
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 103988, 24385, 2645
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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