Invitrogen™ GCK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517711

Catalog No. PIPA517711

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with HPK or other members of the GCK family.

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Specifications

• Antigen: GCK
• Classification: Polyclonal
• Formulation: 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P17712, P35557, P52792
• Gene Symbols: GCK
• Immunogen: Synthetic peptide corresponding to residues surrounding Ser380 of human GCK.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: GCK
• Gene Alias: ATP:D-hexose 6-phosphotransferase; FGQTL3; GC kinase; Gck; Gk; GLK; Gls006; glucokinase; glucokinase (hexokinase 4); glucokinase variant 3; GLUKA; hexokinase 4; hexokinase D, pancreatic isozyme; hexokinase type IV; Hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; Hlb62; HXKP; LGLK; MEKKK 2; MODY2; RNGK2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 103988, 24385, 2645
• Content And Storage: -20°C
• Form: Liquid