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Invitrogen™ GCK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517711

Catalog No. PIPA517711


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Description

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with HPK or other members of the GCK family.

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GCK
Polyclonal
0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
P17712, P35557, P52792
GCK
Synthetic peptide corresponding to residues surrounding Ser380 of human GCK.
100 μL
Primary
Human, Mouse, Rat, Monkey
Antibody
IgG
Western Blot
Unconjugated
GCK
ATP:D-hexose 6-phosphotransferase; FGQTL3; GC kinase; Gck; Gk; GLK; Gls006; glucokinase; glucokinase (hexokinase 4); glucokinase variant 3; GLUKA; hexokinase 4; hexokinase D, pancreatic isozyme; hexokinase type IV; Hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; Hlb62; HXKP; LGLK; MEKKK 2; MODY2; RNGK2
Rabbit
Antigen affinity chromatography
RUO
103988, 24385, 2645
-20°C
Liquid
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