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Invitrogen™ GCK Polyclonal Antibody
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Catalog No. PIPA582275
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100 μL
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PIPA582275 100 μL
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Catalog No. PIPA582275 Supplier Invitrogen™ Supplier No. PA582275
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RLVDENLLFH GEASEQLRTR GAFETRFVSQ VESDTGDRKQ IYNILSTLGL RPSTTDCDIV RRACESVSTR AAHMCSAGLA GVINRMRESR SEDVMRITVG VDGSVYKLHP SFKERFHA Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 94%.

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
TRUSTED_SUSTAINABILITY

Specifications

Antigen GCK
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GCK
Gene Accession No. P35557
Gene Alias ATP:D-hexose 6-phosphotransferase; FGQTL3; GC kinase; Gck; Gk; GLK; Gls006; glucokinase; glucokinase (hexokinase 4); glucokinase variant 3; GLUKA; hexokinase 4; hexokinase D, pancreatic isozyme; hexokinase type IV; Hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; Hlb62; HXKP; LGLK; MEKKK 2; MODY2; RNGK2
Gene Symbols GCK
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GCK. Recombinant protein control fragment (Product #RP-89751).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2645
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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