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Invitrogen™ GCLC Polyclonal Antibody
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Catalog No. PIPA583330
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100 μL
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PIPA583330 100 μL
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Catalog No. PIPA583330 Supplier Invitrogen™ Supplier No. PA583330
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FENSAYVVFV VLLTRVILSY KLDFLIPLSK VDENMKVAQK RDAVLQGMFY FRKDICKGGN AVVDGCGKAQ NSTELAAEEY TLMSIDTIIN GKEGVFPGLI P Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 94%.

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GCLC
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Gclc
Gene Accession No. P48506
Gene Alias cb1049; D9Wsu168e; EGK_15023; fe36e11; gamma GCS-HS; gamma-ECS; Gamma-glutamylcysteine synthetase; gamma-glutamylcysteine synthetase heavy subunit; GCL; Gclc; GCS; GCS heavy chain; Ggcs-hs; GLCL; GLCLC; GLCL-H; glutamate-cysteine ligase catalytic subunit; Glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase, catalytic subunit; Glutamylcysteine gamma synthetase light chain; wu:fe36e11
Gene Symbols Gclc
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GCLC. Recombinant protein control fragment (Product #RP-94586).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2729
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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