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Invitrogen™ GCLC Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5103134
Description
Antibody detects endogenous levels of total GCLC.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Specifications
GCLC | |
Polyclonal | |
Unconjugated | |
Gclc | |
cb1049; D9Wsu168e; EGK_15023; fe36e11; gamma GCS-HS; gamma-ECS; Gamma-glutamylcysteine synthetase; gamma-glutamylcysteine synthetase heavy subunit; GCL; Gclc; GCS; GCS heavy chain; Ggcs-hs; GLCL; GLCLC; GLCL-H; glutamate-cysteine ligase catalytic subunit; Glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase, catalytic subunit; Glutamylcysteine gamma synthetase light chain; wu:fe36e11 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
100522018, 14629, 25283, 2729 | |
-20°C | |
Liquid |
Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P19468, P48506, P97494 | |
Gclc | |
A synthesized peptide derived from human GCLC(Accession P48506), corresponding to amino acid residues K73-N123. | |
100 μL | |
Primary | |
Human, Mouse, Rat, Pig | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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