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MilliporeSigma™ Gcn5, Rabbit, Unlabeled, Polyclonal,

Catalog No. ABE1934MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABE1934MI 100 μL Unconjugated
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Catalog No. ABE1934MI Supplier MilliporeSigma™ Supplier No. ABE1934
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Description

Rabbit Polyclonal Antibody

Histone acetyltransferase KAT2A (EC 2.3.1.48; UniProt Q92830; also known as General control of amino acid synthesis protein 5-like 2, hGCN5, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97) is encoded by the KAT2A (also known as GCN5, GCN5L2, HGCN5) gene (Gene ID 2648) in human. Histone acetyltransferases (HATs) are transcription co-activators recruited by transcriptional activators to target gene promoters, where they enhance the transcription activity by acetylating lysine residues within the N-terminal regions of histones. KAT2A/KAT2B, MYST (MOZ, Ybf2 (Sas3), Sas2, and Tip60), TAFII250, CREBBP/EP300, and SRC represent the five HAT families. In addtion to functioning as transcription co-activators, KAT2A (GCN5) and KAT2B (PCAF) are also reported to repress IFN‐β production and innate antiviral immunity by inhibiting the innate immune signaling kinase TBK1 in the cytoplasm in a HAT‐independent and non‐transcriptional manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Gcn5
Applications ChIP Assay, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene KAT2A, GCN5, GCN5L2, HGCN5
Gene Accession No. Q92830
Host Species Rabbit
Immunogen Ovalbumin-conjugated linear peptide corresponding to the N-terminal sequence of human Gcn5.
Purification Method Protein A Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_066564
Test Specificity This polyclonal antibody was raised against human KAT2A isoform GCN5-L N-terminal sequence that is 95% conserved in murine and rat Kat2a/Gcn5, but missing in human spliced isoform GCN5-S (UniProt Q92830-2).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
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For Research Use Only. Not for use in diagnostic procedures.

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