Invitrogen™ GCNT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109759

Catalog No. PIPA5109759

Description

Immunogen sequence: FVSVRHLELA GENPSSDINC TKVLQGDVNE IQKVKLEILT VKFKKRPRWT PDDYINMTSD CSSFIKRRKY IVEPLSKEEA EFPIAYSIVV HHKIEMLDRL LRAIYMPQNF YCIHVDTKSE DSYLAAVMGI ASCFSNVFVA SRLESVVYAS WSRVQADLNC MKDLYAMSAN WKYLINLCGM DFPIKTNLEI VRKLKLLMGE NNLETERMPS HKEERWKKRY EVVNGKLTNT GTVKMLPPLE TPLFSGSAYF VVSREYVGYV L.

Glycosylation is one of the most universal but at the same time complex protein modifications. Modification with sugar moeties can be both co- translational and post- translational, occurring in the endoplasmatic reticulum and golgi. Three different forms of glycosylation can be distinguished: N-linked oligosaccharides, O-linked oligosaccharides and glycosyl- phosphatidylinositol (GPI-) anchors. Glycosylation results in thousands of distinct, bioactive glycoproteins resident throughout the cell that strongly determine protein-protein, carbohydrate-protein, membrane, and adhesion properties. Diseases associated with glycosylation defects include Congenital disorders of glycosylation, (CDG), also known as carbohydrate deficient glycoprotein syndromes, and diseases associated with advanced aging.

Specifications

• Antigen: GCNT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GCNT1
• Gene Alias: 5630400D21Rik; B130048E03; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N--acetylglucosaminyltransferase; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Core 2 branching enzyme) (Core2-GlcNAc-transferase) (C2GNT); beta1,6 N-acetylglucosaminyltransferase; beta-1,6-N-acetylglucosaminyltransferase; C2 GlcNAcT; C2GNT; C2GNT1; C2GNT-L; core 2 beta1,6 N-acetylglucosaminyltransferase-I; core 2 beta-1,6-N-acetylglucosaminyltransferase I; core 2 branching enzyme; core 2 GlcNAc-T; core 2 GnT; core 2-branching enzyme; Core2-GlcNAc-transferase; enzymatic glycosylation-regulating; G6NT; Gcnt1; glucosaminyl (N-acetyl) transferase 1, core 2; glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase); glucosaminyl transferase 1, core 2; IGnT; NACGT2; NAGCT2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2650
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.94 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q02742
• Gene Symbols: GCNT1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human GCNT1 (NP_001091103.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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