Invitrogen™ GCP4 Monoclonal Antibody (GT812)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA517294

Catalog No. PIMA517294

Description

Recommended positive controls: HeLa. Predicted reactivity: Mouse (97%), Zebrafish (90%), Xenopus laevis (90%), Rabbit (97%), Chimpanzee (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The gamma-Tubulin complex is composed of gamma Tubulin and the gamma-Tubulin complexassociated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. gamma-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the gamma-Tubulin complex. GCP4 (gamma-Tubulin complex component 4), also known as TUBGCP4, is a ubiquitously expressed 667 amino acid member of the gamma-Tubulin complex that localizes to the metaphase spindle during mitosis. In response to proteosome inhibition, GCP4 exhibits increased accumulation at the pericentiolar material where it participates in microtubule organization and nucleation.

Specifications

• Antigen: GCP4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q9UGJ1
• Gene Symbols: TUBGCP4
• Immunogen: Recombinant protein fragment contains a sequence corresponding to a region within amino acids 1 and 178 of GCP4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot, Immunocytochemistry
• Clone: GT812
• Conjugate: Unconjugated
• Gene: TUBGCP4
• Gene Alias: 4932441P04Rik; 76P; D2Ertd435e; gamma tubulin ring complex protein; gamma tubulin ring complex protein (76p gene); gamma-ring complex protein 76 kDa; Gamma-tubulin complex component 4; GCP4; GCP-4; Grip76; h76p; hGCP4; hGrip76; MCCRP3; RGD1306924; TUBGCP4; tubulin gamma complex associated protein 4; tubulin, gamma complex associated protein 4
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 27229
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid