Invitrogen™ GDAP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555052

Catalog No. PIPA555052

Description

Immunogen sequence: ILHPELTVDS MIPAYATTRI RSQIGNTESE LKKLAEENPD LQEAYIAKQK RLKSKLLDHD NVKYLKKILD ELEKVLDQVE TELQRRNEET PEEGQQPWLC GESFTLADVS LAVTLHRLKF LGFARRNWGN GKRPNLETYY ERV Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 97%.

Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 (ganglioside-induced differentiation-associated protein 1) is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.

Specifications

• Antigen: GDAP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GDAP1
• Gene Alias: Charcot-Marie-Tooth neuropathy 4A; CMT4; CMT4A; CMTRIA; ganglioside induced differentiation associated protein 1; ganglioside-induced differentiation-associated protein 1; ganglioside-induced differentiation-associated-protein 1; Gdap1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54332
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8TB36
• Gene Symbols: GDAP1
• Immunogen: Recombinant protein corresponding to Human GDAP1. Recombinant protein control fragment (Product #RP-90928).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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