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Invitrogen™ GDAP1 Polyclonal Antibody
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Catalog No. PIPA5109760
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100 μL
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PIPA5109760 100 μL
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Catalog No. PIPA5109760 Supplier Invitrogen™ Supplier No. PA5109760
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MRLNSTGEVP VLIHGENIIC EATQIIDYLE QTFLDERTPR LMPDKESMYY PRVQHYRELL DSLPMDAYTH GCILHPELTV DSMIPAYATT RIRSQIGNTE SELKKLAEEN PDLQEAYIAK QKRLKSKLLD HDNVKYLKKI LDELEKVLDQ VETELQRRNE ETPEEGQQPW LCGESFTLAD VSLAVTLHRL KFLGFARRNW GNGKRPNLET YYERVLKRKT FNKVL.

Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 (ganglioside-induced differentiation-associated protein 1) is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GDAP1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GDAP1
Gene Accession No. O88741, Q8TB36
Gene Alias Charcot-Marie-Tooth neuropathy 4A; CMT4; CMT4A; CMTRIA; ganglioside induced differentiation associated protein 1; ganglioside-induced differentiation-associated protein 1; ganglioside-induced differentiation-associated-protein 1; Gdap1
Gene Symbols GDAP1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14545, 312890, 54332
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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