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Invitrogen™ GDF15 Polyclonal Antibody
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Catalog No. PIPA5120025
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PIPA5120025 100 μL
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Catalog No. PIPA5120025 Supplier Invitrogen™ Supplier No. PA5120025
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Description

Rabbit Polyclonal Antibody

Positive test controls include: PC-3, HT-1080. The target is usually found in the following locations: Secreted. Immunogen sequence: EDSRFRELRK RYEDLLTRLR ANQSWEDSNT DLVPAPAVRI LTPEVRLGSG GHLHLRISRA ALPEGLPEAS RLHRALFRLS PTASRSWDVT RPLRRQLSLA RPQAPALHLR LSPPPSQSDQ LLAESSSARP QLELHLRPQA ARGRRRARAR NGDHCPLGPG RCCRLHTVRA SLEDLGWADW VLSPREVQVT MCIGACPSQF RAANMHAQIK TSLHRLKPDT VPAPCCVPAS YNPMVLIQKT DTGVSLQTYD DLLAKDCHCI.

GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GDF15
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.99 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene Gdf15
Gene Accession No. Q99988
Gene Alias Gdf15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1; MIC1; MIC-1; NAG1; NAG-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; placental TGF-beta; Prostate differentiation factor; PTGFB; PTGF-beta; SBF
Gene Symbols Gdf15
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9518
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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