Invitrogen™ GDF15 Recombinant Rabbit Monoclonal Antibody (10K4Y8)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA551358

Catalog No. FEMA551358

Description

Immunogen sequence: HLHLRISRAA LPEGLPEASR LHRALFRLSP TASRSWDVTR PLRRQLSLAR PQAPALHLRL SPPPSQSDQL LAESSSARPQ LELHLRPQAA RGRRRARARN G.

GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.

Specifications

• Antigen: GDF15
• Classification: Recombinant Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q99988
• Gene Symbols: Gdf15
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GDF15 (NP_004855.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Western Blot
• Clone: 10K4Y8
• Conjugate: Unconjugated
• Gene: Gdf15
• Gene Alias: Gdf15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1; MIC1; MIC-1; NAG1; NAG-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; placental TGF-beta; Prostate differentiation factor; PTGFB; PTGF-beta; SBF
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9518
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG