Invitrogen™ GDF6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520568

Catalog No. PIPA520568

Description

A suggested positive control is SK-N-SH cell lysate. PA5-20568 can be used with blocking peptide PEP-0688.

GDF6 is a growth differentiation factor (GDFs), which are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.

Specifications

• Antigen: GDF6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GDF6
• Gene Alias: BMP13; BMP-13; Bone morphogenetic protein 13; CDMP2; GDF16; GDF6; Gdf-6; growth differentiation factor 16; growth differentiation factor 6; growth/differentiation factor 16; Growth/differentiation factor 6; KFM; KFS; KFS1; KFSL; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome; LCA17; MCOP4; MCOPCB6; SCDO4; SGM1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 242316, 252834, 392255
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P43028, Q6HA10, Q6KF10
• Gene Symbols: GDF6
• Immunogen: A 17 amino acid peptide near the carboxy terminus of the human GDF6.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG