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Invitrogen™ GDF6 Polyclonal Antibody
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Catalog No. PIPA560947
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PIPA560947 100 μL
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Catalog No. PIPA560947 Supplier Invitrogen™ Supplier No. PA560947
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IYRTYSIAEK LGINASFFQS SKSANTITSF VDRGLDDLSH TPLRRQKYLF DVSMLSDKEE LVGAELRLFR QAPSAPWGPP AGPLHVQLF Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.

GDF6 is a growth differentiation factor (GDFs), which are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GDF6
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GDF6
Gene Accession No. Q6KF10
Gene Alias BMP13; BMP-13; Bone morphogenetic protein 13; CDMP2; GDF16; GDF6; Gdf-6; growth differentiation factor 16; growth differentiation factor 6; growth/differentiation factor 16; Growth/differentiation factor 6; KFM; KFS; KFS1; KFSL; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome; LCA17; MCOP4; MCOPCB6; SCDO4; SGM1
Gene Symbols GDF6
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GDF6. Recombinant protein control fragment (Product #RP-91946).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 392255
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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